You can't live without NAD+.
The bad news: NAD+ levels are destroyed by aging, inflammation, diet, stress, and sickness. This leads to weakness, frailty, and even faster aging.
The good news: You can help restore your NAD+ levels with exercise, nutrition, and targeted supplement formulas.
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NAD+ precursor response is personal.
The enzymes that rebuild your NAD+ stores vary by person and tissue, so the same supplement doesn’t always produce the same effect.
Supporting multiple pathways with NMN, NR, and Trigonelline helps you get reliable, steady NAD+ support without guesswork.
NAD+ boosters like NMN and NR are only the beginning.
After years of analyzing the research, we've aligned with a systems-level approach to address four main pathways to support healthy NAD+ levels throughout the entire body. This systems-level approach is described elegantly by Nichola Conlon and Dianne Ford in a recent study on NAD+ restoration.
Every Renue By Science formula helps you maximize NAD+ through one of these pathways.
Boost
Protect
Optimize
Regenerate
Quality is A Top Priority
Product quality and testing are a priority. We utilize meticulous and extensive 3rd party testing on our products. Each product goes through raw material testing, purity and stability testing – in addition to testing the final product, which many companies do not do.
After production, we send the finished product to test that the capsules or jar has the amount specified on the bottle. That product assurance test has the batch number of the bottle, so customers can confirm the bottle they purchase truly has the quantity of active ingredients specified on the bottle.
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Raw material testing
Purity — Heavy metals — Endotoxins — Mold
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Product assurance
Measuring the quantity of active ingredient per capsule or jar
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Stability testing
Periodic testing to ensure degradation is minimal
The Roles of NAD+
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Energy Metabolism
NAD+participates in the reactions that turn food into ATP inside mitochondria. It also supports the electron transport chain, which fuels nearly every cellular function.
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DNA Access & Repair Signaling
NAD+ is consumed by PARP enzymes involved in the cellular response to everyday DNA stressors. Sustaining NAD+ helps ensure these maintenance pathways have the coenzyme they need.
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Sirtuin Activity
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Mitochondrial Function
NAD+availability supports pathways that help mitochondria produce energy efficiently and manage oxidative workload.
Why NMN belongs inyour daily routine.
By promoting healthy NAD+ levels, NMNhelps:
Support steady energy metabolism by feedingmitochondrial pathways.
Support DNA maintenance signaling, which reliesOn NAD+.
Support sirtuin-linked longevity pathways involved incellular housekeeping.
Together with sleep, protein intake, movement, andsunlight, NMN offers a science-grounded way to supporthealthy aging from the cellular level up.
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Supports Energy Metabolism
NAD+participates in the reactions that turn food into ATPinside mitochondria. It also supports the electrontransport chain, which fuels nearly every cellularfunction.
Supports Brain-Health Cellular Pathways
NAD+participates in the reactions that turn food into ATPinside mitochondria. It also supports the electrontransport chain, which fuels nearly every cellularfunction.
Supports DNA Maintenance & CellularHealth
Sirtuins rely onNAD+to influence cellular housekeeping,metabolic signaling, and chromatin regulation-factorstied to how cells adapt to stress and maintain efficiency.
Supports Vascular & Endothelial Function
NAD availability supports pathways that helpmitochondria produce energy efficiently and manageoxidative workload.
Supports Metabolic Flexibility
Sustaining healthy NADt helps the cellular machinerythat coordinates how we use and switch among fuelsources from food.
The cellular energy crisis.Why Modern Life Destroys NAD+:
Blue light exposure disrupts circadian .NAD+.
Processed foods are inflammatory and increase CD38.
Chronic stress means constant repair demand.
Sedentary lifestyle damages mitochondrial function.
Poor sleep shortens or eliminates nightly recovery window.
Alcohol detoxification depletes NAD+ stores.
The mismatch: Your body expects feast/famine cycles, sunrise/sunset rhythms, and physical demands. Instead, it gets constant food, artificial light, and Netflix.
The solution: Since we can't live like our ancestors, we need to supplement what modern life depletes.
NAD+ myths debunked.
What the Internet Gets Wrong.
Why NMN is helpful for healthy aging.
Aging inyoves cumulatve cellular work oxtdative lood, DNA maintenance, and changing inflommotory tone, all of which increase demandforNAD. When supply lags behind demand, cels may struggle to keep pace. Damage can accumulate and cells may struggle between repair
and normal daily functions.
Bridging the NAD+ gap with NMN.
LowerNAD+availability can contribute to sluggish energy,slower bounce-back after activity, and less adaptablemetabolism.
Adding NMN supplies precursor material your cells canuse to sustainNAD+, helping to:
- Re-energize mitochondrial pathways for day-to-day vitality.
- Support DNA maintenance workflows that relyOn NAD+.
- Activate NAD+-dependent housekeeping linked tohealthy aging.
- Support overall immune readiness within normal,healthy reactions.
- Encourage metabolic flexibility as part of abalanced routine.
Pure and effective: why chooseRenue Pure NMN Powder?
High purity:99.9% NMN, independently verified; no fillers or flow
agents.
Quality you can verify: COA for every lot; identity and purityconfirmed (HPLC/NMR); screened for heavy metals andmicrobes.
Manufactured under cGMP: Consistent processes and batchtraceability.
Easy and versatile:Mix with water; some customers prefer to holdunder the tongue before swallowing.
Storage: Tightly closed; cool, dry place; no refrigeration required.
Full 3 month supply in 1 jar: take one (1) level scoop twice daily. Taking2 doses per day, 100g will last over 3 months.
Is it just aging, or are your NAD+ pathways slowing down?
When one pathway stalls, your energy suffers.
NAD+ is essential for energy, repair, and resilience. As we age, NAD+ synthesis pathways slow down, leading to a dramatic drop in cellular energy. By age 50, we have half of what we did when we were younger. Factors like poor diet, sedentary lifestyles, illness, and environmental toxins deplete NAD+ even faster.
Our scientifically designed multi-pathway formulas restore NAD+ where your biology needs it most.
Our Team
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Bryan Nettles
Nutrition and exercise have been a primary focus for me throughout my life. My passion is in science and research, especially as it relates to healthy aging.
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Dr. Rebecca Crews
Dr. Rebecca Crews is the Research Director at Renue by Science, leading the company’s engagement in transformative research.
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Dr. Clark Driggers
Dr. Clark Driggers, serves as the Chief Medical Advisor at Renue By Science, specializing in wellness, anti-aging, and regenerative medicine.
Common Questions.
Can't l just take NMN?
Can't l just take NMN?
You can, but you're leaving 75% of the benefits on the table. It's likehaving a sports car but only using first gear.
How long untilIfeel results?
How long untilIfeel results?
Most people notice energy improvements in 3-7 days. Deeperbenefits (recovery, cognitive, metabolic) typically emerge by week3-4.
Is this safe long-term?
Is this safe long-term?
Every ingredient has extensive safety data in human and animalmodels. Our dosing strategies reflect the standards set byresearchers for safe use.
This sounds too good to be true?
This sounds too good to be true?
It would be if we were claiming one pill fixes everything. We're not.This is about systematically addressing multiple failure points in awell-studied biological system. The research is published in Science,Nature, Cell, established scientific journals, not wellness blogs.
Why doesn't my doctor know about this?
Why doesn't my doctor know about this?
Medical education focuses on disease treatment, notoptimization.NAD+biology has exploded in the last decade. Mostphysicians trained before this research emerged, and even if it wascovered, most doctors aren't focused on longevity as a subspecialty.Additionally, you can't patentNAD+or its precursors since they'renatural molecules and are made inside the body, so there's limitedpharmaceutical interest in education for funding reasons.
Does this just make expensive urine?
Does this just make expensive urine?
Valid concern. RawNAD+precursors without supporting pathways canhave poor utilization. That's exactly why the four-pathway approachexists: to ensure what you take gets used, not excreted. The PROTECTpathway specifically addresses this by reducing wastefulconsumption.
What about side effects?
What about side effects?
At physiological doses, side effects are minimal. Some peopleexperience initial sleep changes (as circadian rhythms adjust), ordigestive changes (as the microbiome adapts). These typicallyresolve within days. Start low, increase gradually. Always check foringredient interactions if you're on prescriptions or are under thecare of a physician.